Association between Non-Alcoholic Steatohepatitis-Related Hepatocellular Carcinoma and Periodontopathic Bacteria: A Cross-Sectional Pilot Study

The incidence of non-alcoholic steatohepatitis (NASH)-related hepatocellular carcinoma (HCC) is increasing annually as the metabolic syndrome factors increase. This study aimed to analyze involvement periodontopathic bacteria in NASH-related HCC (NASH-HCC). Questionnaire investigation, periodontal examination, medical and specimen collection (saliva, mouth-rinsed water, peripheral blood) were performed 40 patients with NASH 20 NASH-HCC. Immunoglobulin (Ig) G antibody titers against Porphyromonas gingivalis (p = 0.031) Fusobacterium nucleatum 0.003) significantly higher NASH-HCC group than group. P. F. ratios group; however, only ratio was significant 0.009). Shannon index salivary bacterial flora lower < 0.001). had a IgA concentration 0.007) slower flow rate 0.003). In all participants, showed negative correlation 0.02). Oral possibly associated pathogenesis, levels correlated nucleatum.